| Brewery | Location |
|---|---|
| Spitalbrauerei | Regensburg |
| Spiteful Brewing Company | |
| Spoetzl Brewery | Shiner, Texas |
| Spoonwood Brewing Company | Pittsburgh |
| Sports City Cafe & Brewery | La Jolla, California |
| Sprecher Brewing | Glendale, Wisconsin |
| Spring House Brewing Company | Conestoga, Pennsylvania |
| Springdale | Framingham |
| Springfield Brewing | Springfield, Missouri |
| Springhouse Brewing Co. | |
| SpruceGrove Brewery | Hägersten |
| Spyglass Brewery / Branch & Blade Brewery | |
| Spyglass Brewing Company | Nashua |
| Squam Brewing | Holderness |
| SquareHead Brewing Company | Holbrook, New York |