| The Substance | Bissell Brothers | American IPA | |
| Substance | Brasserie du Bas-Canada | American Imperial Stout | 10.0% |
| Substance BA | Brasserie du Bas-Canada | American Imperial Stout | 10.5% |
| Subsurface: Boysenberry | Hitchhiker Brewing Company | Fruit and Field Beer | 7.0% |
| Subterranean | Structures Brewing | American IPA | 6.7% |
| Subtle Alchemy 001 | Creature Comforts | Saison | 6.1% |
| Subtle Alchemy 002 | Creature Comforts | Saison | 6.1% |
| Subtle Alchemy 003 | Creature Comforts | Saison | 6.1% |
| Subtle Matter | Wildflower Brewing & Blending | | |
| Subtraction | Newport Beach Brewing | | |
| Subtractive Synthesis | Grimm Artisanal Ales | New England IPA | 8.5% |
| Suburban Beverage | Perennial Artisan Ales | Gose | 4.2% |
| Suburban Crocodile | Azvex Brewing Company | New England IPA | 7.1% |
| Suburban Funk | No Label Brewing Company | Wild Ale | 6.8% |
| §ucaba | Firestone Walker Brewing Co. | English Barleywine | 12.5% |