| Simple Math | Angry Chair Brewing | | |
| Simple Means | Jester King Craft Brewery | Altbier | 5.6% |
| Simple Sour | Night Shift Brewing | Wild Ale | |
| Simpler Times | Radix Fermentation | Saison | 5.3% |
| Simpler Times Lager | Trader Joe's Brewing Company | American Adjunct Lager | 6.2% |
| Simplex | Brouwerij De Ranke | Kölsch | 4.5% |
| Simplicité Volontaire | Brasserie distillerie - Champ Libre | | 5.0% |
| Simplicity | Kane Brewing Company | Belgian Pale Strong Ale | 8.7% |
| Simplicity In The Sunset | Tired Hands | Saison | 4.7% |
| Simsalabimcoe For President | Brouwerij Frontaal | New England IPA | 6.0% |
| Simtra | Knee Deep Brewing | Imperial IPA | 11.3% |
| Simulacra | Hudson Valley Brewery | | |
| Simvoe's 4th birthday | Brouwerij Frontaal | English IPA | 8.5% |
| Sin & Remorse | Brouwerij De Molen | American Imperial Stout | 10.0% |
| Sin & Remorse | Haarlems Biergenootschap Jopen | American Imperial Stout | 10.0% |