| Signet: Gin | Freak Folk Bier | Saison | 6.0% |
| Significant | BuckleDown Brewing | American Imperial Stout | 12.0% |
| Signs Following | Holy Mountain | | |
| Signs of erosion | Urban Family Brewing | Saison | 6.2% |
| Sigtuna & Shepherd Neame Barley Wine | Sigtuna Brygghus | English Barleywine | 10.0% |
| Sigtuna Bourbon Imperial Stout | Sigtuna Brygghus | American Imperial Stout | 10.5% |
| Sigtuna Christmas Scottish Strong Ale | Sigtuna Brygghus | English Strong Ale | 9.3% |
| Sigtuna Jumbo DIPA | Sigtuna Brygghus | | 8.0% |
| Sikaru | O'so Brewing Company | Wild Ale | 12.8% |
| Silence | Tuckahoe Brewing Co | | |
| Silence Of Light | Modern Times | American Imperial Stout | 13.0% |
| Silencio | Wicked Weed | American Brown Ale | 7.4% |
| Silent Barrel #1111 La Coterie #3 | Side Project | American Imperial Stout | 15.0% |
| Silent Barrel #587 (La Coterie #1) | Side Project | American Strong Ale | 15.0% |
| Silent Commotion | Heist Brewery | American Imperial Stout | 13.0% |