| Space Trash Bin 2 | Newgrass Brewing Company | Fruit and Field Beer | 6.0% |
| Space wave | Jester King Craft Brewery | Saison | 5.6% |
| Space Waves | Jester King / Jolly Pumpkin | Saison | 5.6% |
| Space Ways | Modern Times | American IPA | 6.7% |
| The Space Where Supernaturals Roam | Burial Beer Co. | | |
| Space-Aged Lager | Big Bang Brewery (Closed) | American Lager | |
| SPACEFORCE! | Three Floyds Brewing | Russian Imperial Stout | 15.0% |
| Spaceman Bob | Holy Mountain | | 4.0% |
| Spaceship Earth | Modern Times | American Pale Ale | 6.4% |
| Spacetime Continuum | Tree House Brewing Company | American Imperial Stout | 11.3% |
| Spacetime Continuum Ultimate Coconut | Tree House Brewing Company | American Imperial Stout | |
| SpaceWalker | Great Lakes Brewery | | |
| Spacewalker American Belgo | Great Lakes Brewing | Belgian IPA | 8.2% |
| Spacious Skies | Family Business Beer Co. | American Lager | 4.0% |
| Spades | Stroom | Irish Red Ale | 5.2% |