| Spruce Tip Silk Porter | Hoppin' Frog Brewery | American Porter | 6.2% |
| Spruce Tipped | Blacklist Beer LLC | Imperial IPA | 9.5% |
| Spruced Traditional Gose | Freigeist Bierkultur | Gose | 5.0% |
| Sprudel | Phase Three Brewing Company | Kölsch | 5.0% |
| Sprung | 5 Stones Craft Brewing | | 6.2% |
| Sprung | Evolution Craft Brewing Company | American Blonde Ale | 4.9% |
| Sprye | MadTree | Rye Beer | 5.0% |
| Spumoni | Listermann Brewing Company | | |
| Sputnik | Austin Beerworks | Russian Imperial Stout | 8.5% |
| Sputnik | Wellington Brewery | | |
| Spyglass | Urban Artifact | Fruit and Field Beer | 4.5% |
| Squall IPA | Dogfish Head Craft Brewery | Imperial IPA | 9.0% |
| Squamish | Brasserie Alpha Brewery | American Pale Ale | 5.2% |
| The Square Ball | North Brewing Co. | | 4.5% |
| Square Feet Wheat | Bavarian Barbarian Brewing Company | | |