| Spider Dance | Wayfinder Brewery | Festbier / Wiesnbier | 5.3% |
| Spider Harness | Modern Times | Berliner Weisse | 6.5% |
| Spies Like Us | Wormtown Brewing Co. | Russian Imperial Stout | 10.5% |
| Spigot Licker | Flat Tail Brewing | American Strong Ale | 18.0% |
| Spike & Jerome's - Collaboration Ale | Terrapin Beer Company | | |
| Spike & Jérôme's Cuvée Délirante (Collaboration Ale) | Brasserie des Franches-Montagnes | English Barleywine | 10.0% |
| Spike & Jérôme’s Cuvée Délirante (Collaboration Ale) | BFM Brasserie Des Franches-Montagnes | English Barleywine | 10.0% |
| Spike Cutlass | Founders Brewing | American Barleywine | |
| Spike Devil Porter | Chatham Brewing, LLC | American Porter | 6.0% |
| Spiked Seltzer | Spiked Seltzer | | |
| Spin Cycle Red Ale | No-Li Brewhouse | English Bitter | 5.8% |
| Spin-off - Tequila Barrel Margarita-style | Taxman Brewing Co. | Fruited Kettle Sour | 8.0% |
| Spinach | Other Half Brewing Co. | Imperial IPA | 7.0% |
| Spinal Remains Pumpkin Stout | Spring House Brewing Company | Pumpkin Beer | 8.5% |
| Spinal tapper | Odd Side Ales | Imperial IPA | |