| Big Bang Brewery (Closed) | San Francisco, California |
| Big Bay Brewing Company | Shorewood |
| Big Belly Brewing Company | Breda, Netherlands |
| Big Bend Brewing Company | Alpine, TX |
| Big Boss Brewing Company | Raleigh, North Carolina |
| Big Buck Brewery | Gaylord, Michigan |
| Big Buck Brewery and Steakhouse #2 | Grand Rapids, Michigan |
| Big City Brewing Co LTD | Kingston |
| Big Ditch Brewing Company | Buffalo |
| Big Dog's Brewing Company | Las Vegas, Nevada |
| Big Drop Brewing Co. | Maidenhead, United Kingdom |
| Big Elm Brewing | Sheffield, Massachusetts |
| Big Grove Brewery | Iowa City |
| Big Hole Brewing | Belgrade, Montana |
| Big Horn Brewing @ The RAM 2 | Wheeling, Illinois |