| Second Line Brewing | New Orleans |
| Second Self Beer Company | Atlanta, Georgia |
| Second Shift Brewing | New Haven, Missouri |
| Second Sin Brewing Company | Bristol, Pennsylvania |
| Second Street Brewery | Santa Fe, New Mexico |
| Second Wedge Brewery | Uxbridge |
| Secret Engine Brewing | Brooklyn, New York |
| The Seed: A Living Beer Project | Atlantic City, New Jersey |
| Seedy Brewing | Canton |
| Seedz Brewery | Union Pier, Michigan |
| Seelen Artesana | Spain |
| Seizoensbrouwerij Vandewalle | Lo-Reninge, Belgium |
| Sekinoichi Shuzo | Iwate, Japan |
| Selfmade Brewery | Moscow, Russian Federation |
| Selin's Grove Brewing Co. | Selinsgrove, Pennsylvania |