| Unknown Beginning | Old Thunder Brewing Company | Old Ale | 10.0% |
| Unknown Bottle | Westminster Brewing Company | | |
| Unknown Soldier | The Livery | Wild Ale | |
| Unleash The Yeast: American Ale | BrewDog Ltd | American Pale Ale | 6.3% |
| Unleash The Yeast: Bavarian Weizen | BrewDog Ltd | Hefeweizen | 6.3% |
| Unleash The Yeast: Belgian Trappist | BrewDog Ltd | Belgian Pale Ale | 6.3% |
| Unleash The Yeast: Pilsen Lager | BrewDog Ltd | American Lager | 6.3% |
| Unlocked | Folkingebrew | New England IPA | 9.5% |
| Unloved | The Veil Brewing Company | | 11.0% |
| Unnamed | Forest & Main | | 6.0% |
| Uno IPA | Stigberget/Omnipollo | Imperial IPA | 8.0% |
| Uno Mas | Hoppers Seafood & Grill | American Lager | |
| Unobtainium | Straight to Ale Brewing | | |
| Unobtainium Barrel-Aged Old Ale | Straight to Ale Brewing | Old Ale | 11.5% |
| Unoccupied Space (Chocolate + Vanilla) | Finback Brewery | | |