| Sprudel | Phase Three Brewing Company | Kölsch | 5.0% |
| Sprung | 5 Stones Craft Brewing | | 6.2% |
| Sprung | Evolution Craft Brewing Company | American Blonde Ale | 4.9% |
| Sprye | MadTree | Rye Beer | 5.0% |
| Spumoni | Listermann Brewing Company | | |
| Sputnik | Austin Beerworks | Russian Imperial Stout | 8.5% |
| Sputnik | Wellington Brewery | | |
| Spyglass | Urban Artifact | Fruit and Field Beer | 4.5% |
| Squall IPA | Dogfish Head Craft Brewery | Imperial IPA | 9.0% |
| Squamish | Brasserie Alpha Brewery | American Pale Ale | 5.2% |
| The Square Ball | North Brewing Co. | | 4.5% |
| Square Feet Wheat | Bavarian Barbarian Brewing Company | | |
| Square Fruit | The Good Beer Company | Flanders Oud Bruin | 5.9% |
| Square Wheels | Town Brewery | New England IPA | 6.2% |
| Squashed | Mother's Brewing Company | Pumpkin Beer | 7.4% |