| Sublimely Self-Righteous Ale | Stone Brewing | Black IPA | 8.7% |
| Subliminal Message | Grimm Artisanal Ales | Wild Ale | 5.0% |
| Sublimo | Stigbergets Bryggeri | | 5.5% |
| Subluminal | Buxton / Stillwater | American Imperial Stout | 10.0% |
| Submersion | Barrier Brewing | | |
| Subourbon Snack | Aslin Beer Company | American Imperial Stout | 12.0% |
| Subsolar | Night Shift Brewing | American IPA | 5.6% |
| Subsonic Speeds | Fieldwork Brewing Co. | American IPA | 6.6% |
| The Substance | Bissell Brothers | American IPA | |
| Substance | Brasserie du Bas-Canada | American Imperial Stout | 10.0% |
| Substance BA | Brasserie du Bas-Canada | American Imperial Stout | 10.5% |
| Subsurface: Boysenberry | Hitchhiker Brewing Company | Fruit and Field Beer | 7.0% |
| Subterranean | Structures Brewing | American IPA | 6.7% |
| Subtle Alchemy 001 | Creature Comforts | Saison | 6.1% |
| Subtle Alchemy 002 | Creature Comforts | Saison | 6.1% |