| Oppermann's Barrel-Aged Neapolitan Milk Stout | Saugatuck Brewing Company | Sweet / Milk Stout | 6.5% |
| Opportunity Cost BA 2022 Anniversary | Corporate Ladder Brewing | | |
| Optimal Wit | Port City Brewing Company | | 4.9% |
| Optimator | Spaten-Franziskaner-Bräu | Doppelbock | 7.2% |
| Optimus In Love - Hallon Stout | Två Feta Grisar | English Stout | 7.0% |
| Optimus Primus | Två Feta Grisar | American Imperial Stout | 9.5% |
| Optimus Rubus | Wiley Roots Brewing Co. | | |
| Option #2 | Rock Bridge | Flanders Red Ale | 5.2% |
| Opulence | Corporate Ladder Brewing | Saison | 3.9% |
| Opulence | Jackie O's Pub & Brewery | Wild Ale | 8.3% |
| Opulence | Westbound & Down | American Imperial Stout | 13.7% |
| Opuntia | Avery Brewing Company | Wild Ale | 6.7% |
| Opus | 4 Hands Brewing Co. | Saison | 5.0% |
| Opus Kriek | Arclight Brewing Company | Fruit Lambic | 5.3% |
| Opus Reserve | Whiskey Hill Brewing Company | English Barleywine | 19.5% |