| Spirit of Skully #1 Barleywine | Paradox Beer Company | American Barleywine | 15.5% |
| Spirit Talons | Horus Aged Ales | American Imperial Stout | 13.6% |
| Spirits of the Dead | Ex Novo Brewing | American IPA | 7.3% |
| Spiritu Fornicationis | Microbrasserie Goudale | | 9.5% |
| Spiritual Needs | Cigar City Brewing | American Imperial Stout | |
| Spiritual Unrest | Tree House Brewing Company | Sweet / Milk Stout | 8.0% |
| Spiritus Mundi | Incendiary Brewing Company | American Imperial Stout | 13.0% |
| Spiritus Mundi - Coffee & Coconut | Incendiary Brewing Company | American Imperial Stout | 13.0% |
| Spiteful IPA | Spiteful Brewing Company | American IPA | 6.2% |
| Spitfire | Santiam Brewing Company | Extra Special / Strong Bitter (ESB) | 6.2% |
| Spitfire Best Bitter | Flyers Restraunt and Brewery | English Bitter | 4.0% |
| Spitfire Premium Kentish Strong Ale | Shepherd Neame | | 4.5% |
| Spittin' Seeds | The Buzz Meadery | | 6.6% |
| Splash | 2 Fools Cider | Fruit and Field Beer | 4.0% |
| The splash | Brussels Beer Project | New England IPA | 6.0% |