| Space-Aged Lager | Big Bang Brewery (Closed) | American Lager | |
| SPACEFORCE! | Three Floyds Brewing | Russian Imperial Stout | 15.0% |
| Spaceman Bob | Holy Mountain | | 4.0% |
| Spaceship Earth | Modern Times | American Pale Ale | 6.4% |
| Spacetime Continuum | Tree House Brewing Company | American Imperial Stout | 11.3% |
| Spacetime Continuum Ultimate Coconut | Tree House Brewing Company | American Imperial Stout | |
| SpaceWalker | Great Lakes Brewery | | |
| Spacewalker American Belgo | Great Lakes Brewing | Belgian IPA | 8.2% |
| Spacious Skies | Family Business Beer Co. | American Lager | 4.0% |
| Spades | Stroom | Irish Red Ale | 5.2% |
| Spaghetti Western | Brewfist brewery | Foreign / Export Stout | 9.0% |
| Spaghetti Western | Prairie Artisan Ales / Brewfist | | |
| The Spaghetti Western Imperial Chocolate Coffee Stout Aged In Grappa Barrels | Brewfist brewery | | 10.8% |
| Spanish Sherry Barleywine | Newburgh Brewing Company | American Barleywine | 12.0% |
| Spank Me Baby! | Tyranena Brewing | American Barleywine | 9.0% |