| Sigil XII | Bissell Brothers | | |
| Sigma | Alvinne Picobrouwerij | Flanders Oud Bruin | 10.0% |
| Sigma | Brouwerij Alvinne | Flanders Oud Bruin | 10.0% |
| Sigma Wild Forest | Brouwerij Alvinne | Flanders Oud Bruin | 8.0% |
| Sign of the Horn | 3 Sons Brewing Co | | |
| Sign of Time | Norm Brewing | New England IPA | 6.8% |
| Signal 8 | 1940's Brewing Company | American Pale Wheat Beer | 5.4% |
| Signal Cues | Sante Adairius Rustic Ales | | 7.0% |
| Signal de Botrange | Elevation Beer Co. | Saison | 7.5% |
| Signal to Noise | Grimm Artisanal Ales | Imperial IPA | 8.5% |
| Signata | Fenetra | | 7.2% |
| Signature | Choc Beer Company | Quadrupel (Quad) | |
| Signature Ale | De Proefbroueweij/Port Brewing | Belgian Pale Strong Ale | 8.5% |
| Signature Imperial Cream Stout | Mad River Brewing Company | American Imperial Stout | 8.0% |
| Signature Pale Ale | Steamworks | American Amber / Red Ale | |