| Operation CoHoperation | Lupulin Brewing/Barrel Theory | | 8.0% |
| Operation Cohoperation | Mumford Brewing | Imperial IPA | 8.0% |
| Operation Doomsday | Brouwerij Frontaal | New England IPA | 8.5% |
| Operation Flintlock Peanut Butter | Listermann Brewing Company | American Stout | 6.0% |
| Operation Freedom | Northern Monk | American IPA | |
| Operation Plowshare | Urban Artifact | Fruit and Field Beer | 7.7% |
| Operation: Nighthawk | The Fermentorium | | 8.5% |
| Operis | Four Winds Brewing | Saison | 7.0% |
| Opgebokt! | Van Moll | Doppelbock | 7.5% |
| Ophion (Vanilla) | Mortalis | | |
| Opia | Hair of the Dog Brewing Company | American Imperial Stout | 12.0% |
| Opperman's Bourbon Barrel Aged Plead The 5th | Dark Horse Brewing Co. | American Imperial Stout | 11.0% |
| Oppermann's Barrel-Aged Neapolitan Milk Stout | Saugatuck Brewing Company | Sweet / Milk Stout | 6.5% |
| Opportunity Cost BA 2022 Anniversary | Corporate Ladder Brewing | | |
| Oppose the Tyrant | 13 Stripes Brewery | | |