| Derivative | Proclamation Ale Company | American Pale Ale | 6.0% |
| Derivative of Dankness | Local Craft Beer | Imperial IPA | 8.0% |
| Derketo | Pipeworks Brewing Company | American IPA | 10.0% |
| Dernière Volonté - Brettanomyces | Brasserie Dieu du Ciel | Belgian Pale Strong Ale | 7.0% |
| Dernière Volonté Réserve Spéciale (Vieillie En Fût De Pinot Noir) | Brasserie Dieu du Ciel | Belgian IPA | 7.0% |
| Des Moines IPA | Confluence Brewing Company | | |
| DESAFINADO | B BOP FERMENTORY | Berliner Weisse | 6.5% |
| Desay Deux | De Garde Brewing | Wild Ale | 6.4% |
| Desay l'Orange | De Garde Brewing | Saison | 6.5% |
| Desayuno Del Diablo | Paranormal Brewing | | 9.5% |
| Descendent Dark Ale | Mystic Brewery | English Stout | 7.0% |
| Descender IPA | GoodLife Brewing Company | American IPA | 7.0% |
| The Descent | Martin House Brewing Company | American Imperial Stout | 12.0% |
| Descent Imperial Abbey Ale | Midnight Sun Brewing Co. | Belgian Dark Strong Ale | 8.3% |
| Desert Ale | Epic Ales | Saison | 7.0% |